HPV-associated cervical cancer is one of the few cancer types that can be effectively prevented through vaccination. Additionally, early diagnosis and effective treatment can lead to complete cure. However, global incidence and mortality rates of cervical cancer remain high, particularly in resource-limited countries and contexts. Therefore, a global global scale-up of HPV screening methods is necessary. Studies conducted in South Africa have shown that self-swabbing, where individuals collect their own samples instead of relying on healthcare professionals, is more widely accepted in certain population groups. We aim to evaluate the feasibility and accuracy of self-swabbing as a method and assess its effectiveness for broad implementation in marginalized migrant contexts. This project will be conducted as a collaborative effort with a partner site in southern Africa that already has experience with this method.