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IPTi: Intermittent Preventive Treatment in Infancy

Intermittent preventive treatment in infancy with sulfadoxine-pyrimethamine (SP) constitutes a rather novel concept of malaria control in African children.

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This Intervention is currently being evaluated in several cohort studies in regions of varying endemicity in Africa. In Tamale, northern Ghana, 1200 infants were recruited at three months of age und followed-up until their second birthday. In this randomised and double-blind trial, 600 children received a therapeutic dose of SP at ages 3, 9, and 15 month, and 600 children received placebo. Regular follow-up visits were schedzuled at three-monthly intervals. Uncomplicated malaria was treated with artesunate for five days. This cohort study was completed at the end of 2005; compliance was in the range of 85%. Ongoing statistical analysis focuses on the comparison of incidences of malaria, anaemia as well as hospital admissions. Ongoing meta-analyses are meant to build the base for a recommendation on the implementation of the intervention measure.

Project Details

Principal Investigator:
Prof. Dr. med. Frank P. Mockenhaupt

Antje Tomschegg
Bärbel Jakob
Ina Danquah
Susanne Röwer

Co-workers, Ghana:
Dr. Eiman Saad
Dr. Felicia Amoo-Sakyi
Dr. Felix Röpcke
Dr. Klaus Reither
Dr. Marc Frempong
Dr. Philip Zanger
Dr. Stephen Dzisi
Peter Ziniel

Dr. Ekkehart Dietz, Institut für Sozialmedizin, Epidemiologie und Gesundheitsökonomie, Charité, Berlin
Dr. Rowland Otchwemah, School of Medicine and Health Sciences, Tamale, Ghana
Dr. Sylvester Anemana, Dr. Elias Sory, Dr. Andrew Seidu, Ministry of Health, Tamale, Ghana
Dr. Teunis Eggelte, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, Amsterdam, Holland

Doctoral students:

Project duration:

Project status:

German Ministry of Education and Research, German Academic Exchange Service (DAAD), Charité


Aponte JJ, Schellenberg D, Egan A, Breckenridge A, Carneiro I, Critchley J, Danquah I, Dodoo A, Kobbe R, Lell B, May J, Premji Z, Sanz S, Sevene E, Soulaymani-Becheikh R, Winstanley P, Adjei S, Anemana S, Chandramohan D, Issifou S, Mockenhaupt F, Owusu-Agyei S, Greenwood B, Grobusch MP, Kremsner PG, Macete E, Mshinda H, Newman RD, Slutsker L, Tanner M, Alonso P, Menendez C. Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet. 2009 Oct 31;374(9700):1533-42.

Danquah I, Dietz E, Zanger P, Reither K, Ziniel P, Bienzle U, Mockenhaupt FP. Reduced efficacy of intermittent preventive treatment of malaria in malnourished children. Antimicrob Agents Chemother. 2009 May;53(5):1753-9.

Mockenhaupt FP, Reither K, Zanger P, Roepcke F, Danquah I, Saad E, Ziniel P, Dzisi SY, Frempong M, Agana-Nsiire P, Amoo-Sakyi F, Otchwemah R, Cramer JP, Anemana SD, Dietz E, Bienzle U. Intermittent preventive treatment in infants as a means of malaria control: a randomized, double-blind, placebo-controlled trial in northern Ghana. Antimicrob Agents Chemother. 2007 Sep;51(9):3273-81.